Group 29 Presentation

Introduction

Materials and Methods

Analysis 1

Analysis 2

  • Wide variations in CD marker distribution.
  • Tissue-related clusters are common
  • Some markers are universally expressed (e.g. CD45), while others are lineage-specific.

Analysis 3

Analysis 4

Number of significant CD markers (p < 0.05)
Lineage Significant CDs
B cells 104
Thymocytes 74
CD4 T cells 51
CD8 T cells 46
  • Table: B cells had the most significant markers, showing stronger activation changes.
  • B cells: Tonsil B cells are more activated (CD69, CD80), while blood B cells mature gradually (CD11a, CD80).
  • CD4 T cells: Mature from thymus to blood, losing CD10 and gaining CD25 and CD4_MEM-241.
  • CD8 T cells: Move from active thymus cells to mature blood cells with higher CD27 and CD95.

Analysis 5

  • CD4 and CD8 T cells go through parallel stages
  • How
Count of significant CDs
Pair Count
SP1ap 24
SP1am 15
Naive 18
CM 23
EM 25
TEMRA 22

Discussion